学位论文详细信息
Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers
Research Article
Van Lehn, Reid C. ; Atukorale, Prabhani U. ; Carney, Randy P. ; Yang, Yu-Sang Sabrina ; Stellacci, Francesco ; Irvine, Darrell J. ; Alexander-Katz, Alfredo
American Chemical Society (ACS)
Others  :  http://dspace.mit.edu/openaccess-disseminate/1721.1/91636
美国|英语
Source: MIT Theses in DSpace@MIT
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【 摘 要 】
Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.
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